When we last saw Amicia and Hugo de Rune at the end of A Plague Tale: Innocence back in 2019, things were looking up for the orphaned rat wranglers. They'd escaped the clutches of the French Inquisition and the hordes of plague rats following in their wake, and the pair were hopeful about finding a cure for the cursed macula flowing through Hugo's veins.
Alas, when I pick up their journey in chapter six of Asobo's upcoming sequel, A Plague Tale: Requiem, Amicia is having a particularly terrible time of it. Not only is she suffering from an open head wound, leaving her unsteady on her feet, but rumours are flying in the nearby pilgrim camp about something bad having gone down in the last city they passed through. Exactly what is hard to say with five chapters' worth of context missing from my preview build, but the pack of guards who are hot on the siblings' trail quickly make it plain: several men died back in that city, and they're pointing the finger squarely at Amicia's knife, slingshot and crossbow.