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If you're jumping back into Cyberpunk 2077 with the release of Phantom Liberty today, be aware that it's possible to lock yourself out of the DLC's main quest.
As reported by PC Gamer, making a particular choice during one of the earlier story quests will lock you out of any future main quests. You can still explore Dogtown, but you won't get to spend time with Idris Elba. Why would you deprive yourself of that opportunity?
The choice which will lock you out is towards the end of Lucretia My Reflection, the fourth main quest. It's a fairly obvious one, but spoiler warning for below if you want to know exactly where it occurs.