Resident Evil 4 remake offers more than a handful of weapons and item options, but only a few could be considered the best. While a majority of the guns from the original game do appear, there are a few new additions that serve more interesting utility roles. Additionally, there is one item in particular that can make the game significantly easier if the player chooses to invest in it.
Editor's Note: Please keep in mind that the weapons and items in the "best of" list below may contain spoilers for the later hours of Resident Evil 4 remake.
Combat Knife
The Combat Knife is an invaluable weapon. It will allow you parry attacks and perform finishers on enemies. Since Resident Evil 4 remake becomes significantly easier once you get the parry mechanic down, upgrading your Combat Knife is a must. Especially when it comes to close quarters combat.
Once fully upgraded, you will be able to take down most normal enemies with just a few slashes on Standard. This also goes for the Fighting Knife, which is a better version of the Combat Knife and is obtained later in the game. Both of these knives have durability. But keeping both in your inventory will more than pay off.
Bolt Thrower and Attachable Mines
With ammunition you can pick up from enemies you kill or from any missed shot, the Bolt Thrower is a great item for those wanting to conserve on ammo. But what makes the Bolt Thrower really stick out is the Attachable Mines you can craft.
This recipe can be purchased from the Merchant, and the investment immediately pays off. Transforming the Bolt Thrower into the Mine Thrower from the original game, you can hit enemies with the Attachable Mines to deal massive damage. This includes any enemies around the target you've hit. You can also shoot bolts with the Attachable Mines into the floor or walls to use as proximity bombs to help zone enemies. Keep in mind, however, that any bolts used with the Attachable Mines cannot be recovered.
Body Armor
This is arguably one of the best items in the game. While it has durability, much like the knives, it will allow you to effectively take no or significantly reduced damage until the body armor breaks. This is especially helpful for specific boss fights or when you're fighting swarms of enemies. It is suggested that you make sure you always have enough money on you to repair the body armor whenever possible.
Stingray
This is the better of the two sniper rifle options. That's mostly because this semi-automatic sniper rifle will allow you to quickly fire off shots with little recoil. This is especially helpful during specific boss fights, especially when there is a fair amount of distance between you and your target. Additionally, this gun is great for taking down Regenerators and Iron Maidens. Sniper rifles are definitely not a necessity in Resident Evil 4 remake, but it's nice to have one around.
These are some of the weapons and items that can make your run of Resident Evil 4 remake a lot easier. That said, when trading the Merchant Spinels for weapon upgrades and attachments, read the description carefully. Only certain attachments will work with specific weapons.
Another good investment, but will require players to complete all of the Merchant's side quests, is the Exclusive Upgrade Ticket if you're looking to completely max out a weapon of your choice entirely for free--including the exclusive upgrade that comes with it.
The Resident Evil 4 remake is available for the PS4, PS5, Xbox Series X, and PC. A playable demo is immediately available.
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